Education and Training

Degrees

1996 Harvard University A.B. Biology
2001 Harvard Medical School M.D. Medicine
2008 Harvard School of Public Health M.P.H. Clinical Effectiveness

Post-Graduate Training

2001-2004 Massachusetts General Hospital Internship and Residency Internal Medicine
2004-2008 Massachusetts General Hospital/Brigham and Women's Hospital Clinical and Research Fellowship Nephrology
2005-2008 Massachusetts General Hospital Research Fellowship Informatics

Board Certifications

2004 American Board of Internal Medicine Internal Medicine
2007 American Board of Internal Medicine Nephrology

Academic Appointments

2014-
Assistant Professor in Medicine

Current Positions

2016
Associate Medical Director of Drug Safety
Biogen
Safety and Benefit Risk
Focused on ensuring new therapies are safe and effective.

Prior

2014-2016
Director of Nephrology Informatics
Massachusetts General Hospital
Division of Nephrology
Oversee all information-technology based initiatives within the Division. These include research activities, clinical activities, and administrative initiatives. Provides informatics support for research ventures.
2014-2016
Associate Physician
Massachusetts General Hospital
Department of Medicine
Serve as attending nephrologist. Cover the inpatient Nephrology consultation, dialysis, and intensive care unit services. Teach and supervise fellows, residents, and students.
2013-2016
Director of Collaborative Informatics
Massachusetts General Hospital
Laboratory of Computer Science
Design, plan, and manage development of Apprentice (web-based clinical workflow and collaboration software used at four Boston-area hospitals) and Mojo (smartphone app for clinical data). Includes development and management of eBridge, a component of Apprentice used as the primary tool for inpatient electronic documentation at Massachusetts General Hospital.
2012-2016
Subspecialty Core Educator
Massachusetts General Hospital
Department of Medicine
Oversee outpatient and inpatient nephrology rotations for medical residents. Developed educational program. Coordinate clinical experiences.
2012-2015
Associate Program Director
Massachusetts General Hospital and Brigham and Women's Hospital
Oversaw nephrology fellowship activities at Massachusetts General Hospital including clinical rotations and research education.
2008-2014
Assistant in Medicine
Massachusetts General Hospital
Department of Medicine
Prior hospital appointment.
2008-2014
Instructor in Medicine
Prior academic appointment.
2005-2006
Chief Resident in Medicine
Massachusetts General Hospital
Department of Medicine
Developed curriculum for internal medicine residency program. Oversaw educational programs and clinical rotations. Introduced web-based platform for program activities. Launched program providing all residents with internet-connected smartphones and developed clinical software for these devices.

Consulting and Monitoring

2015-
Data Safety Monitoring Board Member
Vitamin K and Calcific Uremic Arteriopathy
Massachusetts General Hospital
Review adverse events related to a clinical trial.
2015-
Medical Monitor
A Phase 3b Investigation of Erythropoietin Drugs Using a Specified Dosing Algorithm (PEIDA Study)
Frenova Renal Research
Medical monitor for a randomized controlled trial of erythropoietic agents.
2012-2014
Medical Monitor
Dialysis Infection and Vitamin D in New England (DIVINE Study)
Massachusetts General Hospital
Medical monitor for a randomized controlled trial of ergocalciferol.

National Group Membership

2015-
Nephrology Standing Committee Member
National Quality Forum
Identify priorities to guide national quality standards of care.
2015-
Grant Reviewer
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases
Internet-assisted grant reviewer to assess quality of NIH grant applications.

Awards and Honors

2015
Physician of the Year
Massachusetts General Hospital
Division of Nephrology
Given in recognition of a physician who exemplifies dedication to nephrology education, patient care, and collegiality.
2015
Finalist - Innovation in Kidney Education contest
American Society of Nephrology
Given in recognition of an innovative teaching tool based on effectiveness, appeal and interest, and engagement.
2015
Nominee - Nathaniel Bowditch Prize
Massachusetts General Hospital
Given in recognition of an innovation that improves patient care.
2005-2006
Partners in Excellence Award
Partners Healthcare
Given in recognition of informatics contributions.

Major Areas

Clinical Nephrology and Education

My clinical interests include acid/base physiology, electrolyte disorders, acute kidney injury, and chronic kidney disease. I see inpatients on the consult, ICU, and dialysis services and outpatient receiving chronic hemodialysis. I serve as the Nephrology Subspecialty Core Educator for the MGH Medicine Residency Program.

show more

Peer and Trainee Education

Clinical Research

My research focuses on the biological actions of vitamin D. Particular areas of interest include the effects of vitamin D on the immune system, the role of vitamin D binding protein, and the effects of chronic kidney disease on vitamin D biology. I have been involved in several clinical trials as a principal investigator, co-investigator, medical monitor, and data and safety monitoring board member. I have supervised the research of several nephrology fellows and medical residents. I have served as a reviewer for over 20 peer-reviewed journals and have over 50 publications listed in Pubmed.

show more

Grants

2016-
Fanconi Syndrome, Multiple Sclerosis, and Chronic Kidney Disease
Principal Investigator ($165,209)
The goal of this project is to characterize urinary and renal function changes associated with multiple sclerosis..
2014-2015
Dialysis Extending Longevity With Intensive Vitamin Ergocalciferol Replacement
Massachusetts General Hospital Interim Support Fund
Principal Investigator ($178,250)
The goal of this project is to define the mortality effects of ergocalciferol replacement in patients on hemodialysis.
2014-2015
Multiple Sclerosis and Chronic Kidney Disease
Principal Investigator ($165,209)
The goal of this project is to identify the association between chronic kidney disease and Fanconi's syndrome with multiple sclerosis.
2007-2008
Role of hCAP18/LL37 and Vitamin D in Dialysis Mortality
National Kidney Foundation Research Fellowship
Principal Investigator ($40,000)
The goal of this project was to study inflammatory predictors of mortality in individuals with end-stage renal disease.
2009-2014
Human Cathelicidin (hCAP18) in Chronic Kidney Disease
NIDDK/5K23DK081677
Principal Investigator ($631,250 total)
The goal of this project was to study the effects of vitamin D on the antimicrobial peptide hCAP18/LL37.

Editorial Activities: Ad Hoc Reviewer

  • American Journal of Kidney Diseases
  • American Journal of Nephrology
  • Archives of Internal Medicine
  • BioMed Central Cardiovascular Disorders
  • BioMed Central Nephrology
  • British Journal of Nutrition
  • Circulation
  • Clinical Journal for the American Medical Association
  • Clinical Journal of the American Society of Nephrology
  • Clinical Nephrology
  • Endocrine
  • Family Practice
  • Hemodialysis International
  • International Journal of Clinical Rheumatology
  • International Journal of Endocrinology
  • International Journal of Inflammation
  • Journal of the American Heart Association
  • Journal of the American Society of Nephrology
  • Journal of Clinical Endocrinology and Metabolism
  • Kidney International
  • Nephrology Dialysis Transplantation
  • Obesity
  • Preventing Chronic Disease
  • PLoS One
  • Scientific Reports

Publications

Over 50 publications available in PubMed
→ load now

Informatics

As Director of Collaborative Informatics at the MGH Lab of Computer Science (LCS), I design software aimed at improving clinical communication and streamlining access to clinical information. Recent projects include Apprentice, a web-based platform that facilitates communication between physicians and generates both signout and clinical documentation from a core set of data elements. eBridge is a clinical documentation system built on top of Apprentice that is the main inpatient documentation system at MGH. Apprentice has used by over 2,000 clinicians at Massachusetts General Hospital, Brigham and Women's Hospital, Faulkner Hospital, and Newton-Wellesley Hospital. Mojo, an iOS-based app, allows rapid, secure access to clinical data by mobile devices used by over 1000 clinicians.

show more

Projects

Apprentice Web-based clinical collaboration software that allows for shared patient summaries and interactive task lists designed to improve real-time coordination of care between clinicians and improve handoffs. It provides web-based and printed patient summaries. Apprentice can generate printed progress notes or progress note templates derived from patient summaries or, at supporting institutions, generate fully electronic notes via the eBridge module. It interfaces with centralized patient list management software, clinical laboratories, allergy repositories, medication administration record systems, and other clinical systems.
Mojo Smartphone app designed for secure, remote access to clinical data including patient records, laboratory results, medication information, and clinical documentation. Mojo also provides access to clinical schedules, paging systems, transplant lists, and interfaces with the Apprentice clinical collaboration software (above). It is actively used by over 1,000 clinicians at Massachusetts General Hospital.
eBridge Based on Apprentice, this is the primary inpatient documentation system at Massachusetts General Hospital. Instead of focusing primarily on note creation like traditional systems, eBridge allows multiple providers to contribute to a repository of clinical information in real time. A snapshot using varying components current clinical information can be used to generate electronic documentation or signout forms, reducing redundant documentation and improving efficiency.
Nephromatic This set of nephrology-oriented tools and calculators provides detailed explanations of common formulae used in nephrology, along with suggested interpretations and background information to guide clinicians in their use. Adaptive design allows efficient use by both traditional computers and smartphones.

Computing Skills

My primary role is in overall design, organization, and overseeing execution of software. However, I actively participate in web-based software development using HTML, CSS, JavaScript/jQuery on the front-end and SQL Server, ASP, and Python. I have a working knowledge of Apple's XCode and Objective-C for iOS development. Additional experience includes Git, MS Visual Source Safe, PHP, and JIRA. I have previously used C/C++, Pascal, and Java. I have extensive experience with statistical packages including Stata, SAS, and R.

An interactive version of this resume is available at http://ishirbhan.com